Metabolic Activation of Drugs to Toxic Substances

Persistent Toxic Substances

Annex 12 addresses definitions, general principles, programs, monitoring, early warning system, human health, research, and reporting. This annex embraces the philosophy of zero discharge and the goal of virtual elimination, and the Parties have achieved considerable success in controlling direct, point source discharges of toxic chemicals to the lakes. The Commission finds, however, that there...

The law of toxic substances.

The law of toxic substances dates back to Medieval England, but the present comprehensive federal regulatory scheme was developed over the past two decades. This article presents a brief overview of the federal law of air and water pollution, solid waste control, and the regulation of chemicals.

Prevention, Pesticides and Toxic Substances

OPPT has been assessing perfluor,inated compounds since 1999. This interest was prompted by reports submitted to the agency describing the toxic properties and widespread presence in the environment, including in human populations, of some of these chemicals. Initial efforts focused on perfluorooctane sulfonate (PFOS), and the assessment of ecological and human health hazards was recently publi...

Effects of toxic substances on female reproduction

Successful reproduction requires a complex series of interdependent physiological, cellular and molecular events. In the female many of these interdependent events are vulnerable to interruption by xenobiotic compounds. The physiological steps in the female reproductive cycle are reviewed. Selected xenobiotics which interrupt this cycle are presented and their mechanisms and site of adverse eff...

Regionally Based Assessment of Persistent Toxic Substances